Kisspeptin 5000mcg x 10
PubChem CID 71306396
Molecular Formula C258H401N79O78
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Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005 Dec;90(12):6609-15. doi: 10.1210/jc.2005-1468. Epub 2005 Sep 20. PMID: 16174713.
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Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1761-6. doi: 10.1073/pnas.0409330102. Epub 2005 Jan 21. PMID: 15665093; PMCID: PMC545088.
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Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE. Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci. 2005 Dec 7;25(49):11349-56. doi: 10.1523/JNEUROSCI.3328-05.2005. PMID: 16339030; PMCID: PMC6725899.
These studies cover various aspects of Kisspeptin, including its role as the natural ligand of the orphan G protein-coupled receptor GPR54, its ability to stimulate the hypothalamic-pituitary gonadal axis in human males, its direct stimulation of gonadotropin-releasing hormone release, and its requirement for the luteinizing hormone response in anestrous ewes following the introduction of males.
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